© International Commission on Radiation Units and Measurements 2007
5 GEOMETRIC TERMS, AND DOSE AND DOSE–VOLUME DEFINITIONS
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In previous ICRU reports (ICRU, 1993b; 1999; 2004), a number of important concepts concerning anatomic volumes of interest were introduced and defined. Among these were: for tumors, the gross target volume (GTV), the clinical target volume (CTV), and the planning target volume (PTV); and, for normal tissues, the concepts of organ at risk (OAR) and planning organ at risk volume (PRV).
Except for the PTV and PRV, these definitions apply to all modalities equally. Both in their delineation and in their use, it is irrelevant as to whether photons, electrons, protons, or any other radiation are to be employed. Indeed, it is important not to let knowledge of the likely radiation modality affect how these volumes are delineated since (i) their definitions are
5.1 ANATOMIC VOLUMES RELATING TO THE TUMOR
5.1.1 Gross tumor volume (GTV)
5.1.2 Clinical target volume (CTV)
5.1.2.1 The dose intention for the CTV
5.1.3 Internal target volume (ITV)
5.1.4 Planning target volume (PTV)
5.1.4.1 Margins for the different types of variations and uncertainties
5.1.4.2 Delineating the PTV
5.1.4.3 Multiple PTVs
5.1.4.4 Proton-specific issues regarding the PTV
5.2 ANATOMIC VOLUMES RELATING TO UNINVOLVED NORMAL TISSUES AND ORGANS
5.2.1 Organ at risk (OAR)
5.2.2 Planning organ at risk volume (PRV)
5.2.3 Remaining volume at risk (RVR)
5.3 GENERIC GEOMETRIC TERMS
5.3.1 Volume of interest (VOI)
5.3.2 Target volume (TV)
5.3.3 Surface of interest (SOI)
5.3.4 Point of interest (POI)
5.4 NOMENCLATURE
5.4.1 Multiple GTVs, CTVs, and PTVs
5.4.1.1 One GTV plus a surrounding volume intended to receive the same dose
5.4.1.2 One GTV plus a surrounding volume intended to receive a lower dose
5.4.1.3 No GTV
5.4.1.4 Two spatially separated GTVs
5.4.1.5 Two nested GTVs plus a region of possible microscopic disease
5.4.1.6 Reduced tumor dose in a region closely adjacent to an OAR
5.4.2 Multiple OARs and PRVs
5.4.3 Number of RVRs
5.4.4 Qualification of geometric terms
5.4.4.1 Tumor, nodal, or metastatic basis for a target volume
5.5 VARIATION OF GEOMETRY WITH TIME
5.6 DOSE AND DOSE–VOLUME RELATED DEFINITIONS
5.6.1 One-dimensional dose and dose–volume summarization
5.6.1.1 The volume receiving at least a specified dose (VD)
5.6.1.2 The least dose received by a specified volume (DV)
5.6.1.3 Other dose measures
5.6.2 Two-dimensional dose–volume summarization
5.6.2.1 Two-dimensional dose displays
5.6.2.2 Dose–volume histograms (DVH)
5.6.2.3 Dose–area histograms (DAH)
5.6.3 Prescribed dose
5.6.3.1 Prescribed dose for multiple PTVs
5.6.3.2 Prescribed dose for multiple treatment segments (segment dose)
5.6.4 Relative dose
5.6.5 Treated volume
5.6.6 Conformity index (CI)
5.6.7 Irradiated volume (at a specified dose)
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